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Exposure to 'forever chemicals', air pollution, stress and many other factors depends on where a person lives and their lifestyle choices. These exposures combine over the course of a lifetime, affecting human biology and health. The 'exposome' concept offers a framework for understanding and analysing this complex reality, and ultimately for informing the shaping of evidence-based policy on chemicals, food and the workplace, as well as on pollution, public health and the environment more generally.